VEGA 2/0097/11

Modulation and function of inositol 1,4,5-trisphosphate receptors (IP3R) in neuronal structures of central nervous system (CNS) in normal and pathological conditions        


Principal Investigator: Michaela Pavlovičová

Duration: January 2011 – December 2013
Coordinating Organization: Institute of Molecular Physiology and Genetics SAS, Bratislava


Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular calcium transporters that modulate calcium level in the cell in physiological processes as well as in response to pathological stimuli. In proposed project we want to elucidate functional and regulation involvement of individual IP3Rs into process of degeneration and regeneration of neurons in CNS lesion. We will effort to define the role of IP3R-mediated calcium signaling in „inability“of injured neuron to continue its neurite outgrowth and regeneration in such pathological conditions. In pathological states of CNS fibrotic scar is created and together with cumulated growth inhibitors prevents further outgrowth and reparation of neuron. On in vitro model of CNS lesion, after stimulation and inhibition of neurite outgrowth, we want to define changes of gene expression of individual IP3Rs (mRNA, protein) in neurons as well as changes in IP3-induced calcium release related to such injury.


// >
// ]]>

image Jaskova K, Pavlovicova M, Jurkovicova D (2012): Calcium transporters and their role in the development of neuronal disease and neuronal damage. Gen Physiol Biophys 31:375-382.
Jaskova K, Pavlovicova M, Cagalinec M, Lacinova L, Jurkovicova D (2014): TGFβ1 downregulates neurite outgrowth, expression of Ca2+ transporters, and mitochondrial dynamics of in vitro cerebellar granule cells. NeuroReport 25:340-346.