The Laboratory of Electrophysiology is a research hub dedicated to the study of how excitable cells, neurons and cardiomyocytes, develop and communicate in normal and pathophysiological conditions. Our team combines state-of-the-art patch-clamp electrophysiology with molecular, cellular, and behavioral approaches to investigate the mechanisms that shape neuronal excitability and synaptic function across the life cycle.
Our research spans multiple model systems, including primary hippocampal and midbrain neuronal cultures, iPSC-derived neurons and cardiomyocytes, and brain slices from in vivo models of maternal stress and perinatal pharmacological exposure.
We focus on identifying how genetic variants, such as mutations, application of metabolites like homocysteine, and early-life interventions influence ion channel function, synaptic transmission, and excitatory–inhibitory network balance.
By characterizing ion currents, firing patterns, neuronal synaptic connectivity, and developmental processes, we aim to identify the neuronal mechanisms that shape cognitive and behavioral functions. Laboratory of Electrophysiology provides mechanistic insights essential for understanding the origins of neurodevelopmental and cardiac disorders and to support the development of safer, more targeted treatments in the future.
Contact: prof. RNDr. Ľubica Lacinová, DrSc.
Support: ITMS 26230120006 and Volkswagen grant
